Synthesis and antimicrobial evaluation of some new hydrazo, dihydropyridazinyl and triazolyl derivatives containing indole nucleus

Abstract

Purpose

The aim of this paper is synthesis of some new hydrazo, dihydropyridazinyl and triazolyl derivatives containing indole nucleus and their antimicrobial evaluation.

Design/methodology/approach

Treatment of 3-(1H-indol-3-yl)-3-oxopropanenitrile (1) with different aryl diazonium salts 2a-j gave the corresponding arylazohydrazone derivatives 3a-j. The azo derivatives 3d and 3e were used as the key intermediate for the synthesis of some new diazines 5d, e and triazoles 7d, e. The newly synthesized compounds were characterized by electronic absorption properties – IR, 1HNMR and MS studies – and screened for their biological evaluation. Compounds 3a-j, 5d, e and 7d, e showed promising results as antimicrobial agents.

Findings

Compounds 3a-j, 5d, e and 7d, e showed promising results as antimicrobial agents.

Originality/value

No details regarding the synthesis of such dyes are reported before in the literature.

Citation

Fadda, A., Kandeel, E.E. and El-Gendy, E. (2017), "Synthesis and antimicrobial evaluation of some new hydrazo, dihydropyridazinyl and triazolyl derivatives containing indole nucleus", Pigment & Resin Technology, Vol. 46 No. 2, pp. 122-130. https://doi.org/10.1108/PRT-11-2015-0118