This introduction to the Symposium “Curiosity, Imagination, and Surprise” discusses some of the characteristics of Mary Morgan’s approach to study science, which she labels as “naturalized philosophy of science.” One of these characteristics is the usage of a carefully chosen vocabulary. These concepts are usually unconventional and open-ended with the aim of illuminating the practice under study. Another characteristic of her approach is that it is curiosity-driven, which becomes clear by the kind of typical questions she asks. A third characteristic is that her approach is case-study based, with its typical features, such as the investigation of a bounded “real-life” whole, its attitude of open-endedness, the usage of multiple research methods and its complex, often-narrated outcome.