Relationship between meteorin-like peptide (Metrnl) serum levels and inflammatory cytokines, oxidative stress biomarkers and body composition parameters in type 2 diabetes patients
ISSN: 0034-6659
Article publication date: 28 October 2022
Issue publication date: 5 July 2023
Abstract
Purpose
Meteorin like-peptide (Metrnl) modulates energy hemostasis and relieves inflammation and oxidative stress. This study aims to investigate the relationship between Metrnl levels and inflammatory cytokines, oxidative stress biomarkers and body composition parameters in obese type 2 diabetic patients.
Design/methodology/approach
This analytical cross-sectional study was carried out between August 2020 and March 2021on 93 people (n = 32 obese type 2 diabetic patients, n = 31 healthy obese, n = 30 healthy normal weight). Serum Metrnl levels were measured by enzyme-linked immunosorbent assay. Serum levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), high-sensitivity C-reactive protein (hs-CRP), malondialdehyde and total antioxidant capacity were measured using standard methods. Body composition was assessed by bioelectrical impedance analysis. p-Value less than 0.05 was considered significant.
Findings
Serum Metrnl levels were lower in obese diabetic patients than in healthy normal-weight subjects (82.5 [72.4–94.5] ng/mL compared to 154 [129–189] ng/mL). The difference in Metrnl levels between the two groups was significant (p < 0.001). The difference in Metrnl levels between the two groups was significant. Moreover, a significant correlation between Metrnl level and both TNF-a and hs-CRP was detected (p = 0.006 and p < 0.001, respectively) and the correlation between Metrnl and IL-6 was borderline (p = 0.051). A negative correlation was revealed between Metrnl level and anthropometric measurements and body composition (p < 0.05) with the exception of fat-free mass and skeletal muscle mass.
Originality/value
To discover sufficient evidence for the therapeutic function of Metrnl and its use as a prognostic biomarker in the management of type 2 diabetes mellitus, future clinical studies are needed to highlight other factors influencing Metrnl serum levels.
Keywords
Acknowledgements
The authors would like to acknowledge the financial support of Maragheh University of Medical Sciences for this research. This study was approved by the Ethics Committee of Maragheh University of Medical Sciences with the registered ethics number “IR.MARAGHEHPHC.REC.1398.029”. The authors also thank all participants who contributed to this research.
Citation
Khajebishak, Y., Madani, S., Faghfouri, A.H., Soleimani, A., Ilaei, S., Peyrovi, S. and Payahoo, L. (2023), "Relationship between meteorin-like peptide (Metrnl) serum levels and inflammatory cytokines, oxidative stress biomarkers and body composition parameters in type 2 diabetes patients", Nutrition & Food Science, Vol. 53 No. 5, pp. 861-872. https://doi.org/10.1108/NFS-06-2022-0186
Publisher
:Emerald Publishing Limited
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