Interaction between a variant of vitamin D receptor gene and a posteriori dietary patterns on metabolic syndrome and its components: A nutrigenetic observational study
ISSN: 0034-6659
Article publication date: 26 June 2018
Issue publication date: 10 September 2018
Abstract
Purpose
This paper aims to investigate whether the interaction between vitamin D receptor (VDR) FokI polymorphism and dietary patterns is associated with metabolic syndrome (MetS) and its components.
Design/methodology/approach
In total, 304 Iranians were enrolled in this cross-sectional study. Dietary patterns were identified using factor analysis. Fasting serum glucose and lipid profile were also assessed. FokI polymorphism of the VDR gene was genotyped using the restriction fragment length polymorphism method.
Findings
Individuals in third tertile of “Unhealthy Patterns had greater odds for MetS (odds ratio: 2.9; 95 per cent CI: 1.3, 6.1; P for trend = 0.03) compared to those in first tertile. Significant results disappeared after controlling for covariates (p = 0.09). There was no significant relationship between adherence to ‘Healthy Pattern’ and odds of MetS (p = 0.55). There were not any interactions between FokI polymorphism and major dietary patterns associated with MetS.
Originality/value
No evidence found for the interaction between polymorphism FokI and major dietary patterns associated with MetS and its components in Iranian subjects. Genome-wide association techniques are needed to assess the direct effect of this polymorphism on MetS.
Keywords
Acknowledgements
The authors thank the health houses for their collaboration. They sincerely appreciate all the subjects for their participation in this study.
Source of Funding: This study was funded by Tehran University of Medical Sciences (Grant No. 28040).
Authorship/Contributions: SS-b designed and supervised the study, was involved in laboratory analyses. FS analyzed data and wrote the preliminary manuscript. ZA wrote the finalized manuscript.
Declaration of interests: The authors report no conflicts of interest.
Citation
Shokrzadeh, F., Aslani, Z., Rahimi-Foroushani, A. and Shab-Bidar, S. (2018), "Interaction between a variant of vitamin D receptor gene and a posteriori dietary patterns on metabolic syndrome and its components: A nutrigenetic observational study", Nutrition & Food Science, Vol. 48 No. 5, pp. 780-794. https://doi.org/10.1108/NFS-11-2017-0254
Publisher
:Emerald Publishing Limited
Copyright © 2018, Emerald Publishing Limited